Optimal control of MANF to prevent apoptosis in Retinitis Pigmentosa

11 Jul 2018, 16:30
New Law School/--026 (University of Sydney)

New Law School/--026

University of Sydney

Oral Presentation Minisymposium: Modelling of dynamic cellular and sub-cellular systems Modelling of dynamic cellular and sub-cellular systems


Dr Luis Melara (Shippensburg University)


Protein misfolding is one of the major causes of apoptosis in Retinitis Pigmentosa, where apoptosis is programmed cell death. Mesencephalic-Astrocyte-derived-Neurotrophic Factor (MANF) is a protein that has been shown to correct protein misfolding, thus reducing the death of cells due to “cell suicide”. In this talk, we formulate an optimal control problem that incorporates MANF treatment to rescue photoreceptors in the eye. Numerical results are shown and discussed.

Primary authors

Dr Erika Camacho (Arizona State University) Dr Suzanne Lenhart (The University of Tennessee, Knoxville) Dr Luis Melara (Shippensburg University) Dr M. Cristina Villalobos (The University of Texas, Rio Grande Valley) Dr Stephen Wirkus (Arizona State University)

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