Multiscale modelling of saliva secretion

12 Jul 2018, 11:00
New Law School/--102 (University of Sydney)

New Law School/--102

University of Sydney

Oral Presentation Minisymposium: Internal flows in soft tissue tubes: Evo + Devo + Physio Internal flows in soft tissue tubes: Evo + Devo + Physio


Prof. James Sneyd (University of Auckland)


The parotid salivary gland consists of groups of acinar cells all transporting water into a lumen with a complex branched structure. In addition, each acinar cell itself has a complex spatial structure, with heterogenous spatial distributions of the channels that control water transport. The goal of our model is to determine the relationships between structure and function, both at the level of individual acinar cells, and at the level of the entire salivary gland.

To answer this question we have constructed an anatomically accurate model, based on reconstruction of a z-series of optical slices through a group of acinar cells. Our model shows how the structure of each acinar cell is critical for an understanding of how water flow through each cell is controlled, and how the multicellular branching structure of the lumen can affect total fluid flow.

Primary author

Prof. James Sneyd (University of Auckland)


Prof. David Yule (University of Rochester) Mr Nathan Pages (University of Auckland) Mr Elias Siguenza (University of Auckland) Dr John Rugis (University of Auckland)

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