Gene drive localization and reversal

10 Jul 2018, 10:30
New Law School/--100 (University of Sydney)

New Law School/--100

University of Sydney

Oral Presentation Minisymposium: Modelling Gene Drives Modelling gene drives


Alun Lloyd (North Carolina State University)


Gene drives are a powerful technique to reduce the size of a population or to transform it to become less troublesome. Major concerns include accidental escape of a gene drive, which might lead to widespread elimination of a species, or unintended consequences of released individuals, which might include evolution of resistance to an effector gene. Both spatial localization of a gene drive and the ability to reverse a gene drive are desirable mechanisms to increase the safety of drives. A number of such approaches have been proposed in the literature. Using mathematical modelling, we will explore their likely efficacy and discuss critical weaknesses.

Primary author

Alun Lloyd (North Carolina State University)


Ms Jaye Sudweeks (North Carolina State University) Mr Michael Vella (North Carolina State University) Dr Sumit Dhole (North Carolina State University) Dr Fred Gould (North Carolina State University)

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