Liver spatial heterogeneities and HBV

10 Jul 2018, 11:30
New Law School/--102 (University of Sydney)

New Law School/--102

University of Sydney

Oral Presentation Minisymposium: Modelling memory in physiological regulation Modelling memory in physiological regulation


Shawn Means (University of Auckland)


The liver is a spatially complex and heterogeneous network of blood and bile flows coupled with metabolic processing and a favoured target for infection by hepatic viruses. We present here a mathematical model aimed at investigating these intrinsic heterogeneities and their impact on the dynamic of the Hepatitis-B variant (HBV). Dramatic spatio-temporal scaling from individual hepatocytes to the entire liver organ invites multi-scale approaches inspiring assembly of sinusoid-level 'unit models' into a whole organ representation. Each 'unit-model' sinusoid combines individual hepatocytes communicating with blood flow in the sinus in turn connected with other 'unit-model' sinusoids aggregated into a whole liver modelling scheme. This permits investigating impacts on the whole organ of precisely distributed spatial heterogeneities such as varying HBV uptake mechanisms (e.g., the sodium-taurochloriate cotransporter or NTCP), immune cell responses (e.g., cytolytic or interferon-based) and simple efficiency of HBV replication. We present our results showing how heterogeneities of, in particular, HBV replication efficiencies may be responsible for persistent chronic infections.

Primary author

Shawn Means (University of Auckland)


Dr Harvey Ho (University of Auckland) Mr Quentin Cangelosi (Institut National des Sciences Appliquees)

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