How the extracellular matrix promotes the growth of ovarian cancer

12 Jul 2018, 15:30
New Law School/--024 (University of Sydney)

New Law School/--024

University of Sydney

Oral Presentation Minisymposium: Mathematical models of cell motility and cancer progression in microenvironment Mathematical models of cell motility and cancer progression in microenvironment: design, experiments, mathematical framework, and hypothesis test


Pantea Pooladvand (University of Sydney)


Epithelial Ovarian Cancer (EOC) is one of the deadliest cancers in women. It is the fifth leading cause of cancer-related deaths in the United States. Due to the lack of early detection, this cancer has an average 5-year survival of only 27%. We know, that like other epithelial cancers, ovarian tumour cells remodel the extracellular matrix (ECM) components in healthy tissue in order to promote a favourable environment for replication and progression. However, the role of ECM in promoting EOC is yet to be explored. In this presentation, we aim to highlight some of the key ECM components that play a major role in the progression of tumour cells. We do this by considering the ECM as a dynamic system that can support and protect tumour cells by adapting its components. Using a system of networked ordinary differential equations, we model the tumour environment and show that, to understand the role of the ECM in tumour progression, we must consider the ECM as a collective entity and not just as individual components.

Primary author

Pantea Pooladvand (University of Sydney)


Peter Kim (University of Sydney)

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