Temperature sensitivity of PO/AH neurons

10 Jul. 2018, 11:30 am
30m
New Law School---026 (University of Sydney)

New Law School---026

University of Sydney

100
Oral Presentation Minisymposium: Mathematics Neuroscience Subgroup Mathematics neuroscience subgroup

Speaker

Martin Wechselberger (University of Sydney)

Description

Thermoregulatory responses are partially controlled by the preoptic area and anterior hypothalamus (PO/AH), which contains a mixed population of temperature-sensitive and insensitive neurons. In [1] based on physiological data, a Hodgkin-Huxley-like conductance based model was constructed. This model suggests that most PO/AH neurons have the same types of ionic channels, but different levels of channel expression can explain the inherent properties of the various types of temperature-sensitive and insensitive neurons which is encoded in their frequency sensitivity relative to temperature.

Here we present a detailed bifurcation analysis of this model to confirm these observations. We focus on three main physiological bifurcation parameters, the temperature T and the maximum conductances of two specific background potassium leak channels, $g_{task}$ and $g_{trek}$, that are known to be expressed in these PO/AH neurons. These three bifurcation parameters are sufficient to explain the dynamics of PO/AH neurons observed in experiments.

If time permits, we also discuss the multiple timescales inherent in this model and explain the creation of action potentials based on a geometric singular perturbation analysis.

[1] Wechselberger et al., 2006

Primary authors

Martin Wechselberger (University of Sydney) Mr Timothy Roberts (University of Sydney)

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