Volume transmission and neurotransmitter homeostasis

10 Jul 2018, 10:30
New Law School/--026 (University of Sydney)

New Law School/--026

University of Sydney

Oral Presentation Minisymposium: Mathematics Neuroscience Subgroup Mathematics neuroscience subgroup


Prof. Janet Best (The Ohio State University)


In volume transmission, neurons in one brain nucleus send their axons to a second nucleus where neurotransmitter is released into the extracellular space. In [1] we showed how to calculate the average amount of neurotransmitter at different parts of the extracellular space, depending on neural properties and the geometry of the projections and extracellular space. We showed how to formulate questions as boundaries value problems for the heat equation with stochastically switching boundary conditions, and we derived results in one space dimension.

Here we discuss the two- and three-dimensional problems, along with mechanistic models of neurotransmitter homeostasis.

[1] Lawley, Best, Reed 2016

Primary authors

Prof. Janet Best (The Ohio State University) Prof. Sean Lawley (University of Utah) Prof. H. F. Nijhout (Duke University) Prof. Mike Reed (Duke University)

Presentation Materials

There are no materials yet.