The role of cytoplasmic proteins on cell polarity formation of asymmetric cell division

9 Jul 2018, 18:00
Holme Building/--The Refectory (University of Sydney)

Holme Building/--The Refectory

University of Sydney

Board: 102
Poster Presentation Biochemistry and Cell Biology Poster Session


Tomohiro Nakahara (Hiroshima University)


Asymmetric cell division is one of the widespread mechanisms for generating cell diversity, for which a mother cell creates a polarity in both membrane and cytosol. In both experiment and theoretical approaches, PAR polarity of C. elegans embryo has been extensively well-studied and it was found that Anterior-Posterior (AP) polarity of cell membrane proteins plays a crucial role in determining cell asymmetry. However, most of previous studies have not considered the role of cytoplasmic proteins on AP polarity formation, although AP polarity is occurred with a tight regulation of both membrane and cytoplasmic proteins such as MEX-5/6 and PAR- 5. Here, we develop a multi-dimensional polarity model including cell’s geometrical property and show how the cytoplasmic protein plays an important role in creating a robust AP polarity. We also show that the cell geometry can give a critical effect on AP polarity, and the temporal and spatial regulation for the robust AP polarity is based on the harmony of biochemical, mechanical, and cell geometric properties.

Primary author

Tomohiro Nakahara (Hiroshima University)


Sungrim Seirin-Lee (Hiroshima University)

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