The influence of molecular reach and diffusivity on the effectiveness of membrane-confined reactions

9 Jul 2018, 18:00
Holme Building/--The Refectory (University of Sydney)

Holme Building/--The Refectory

University of Sydney

Board: 108
Poster Presentation Biochemistry and Cell Biology Poster Session


Dr Ying Zhang (Boston University)


Tethered enzymatic reactions are a key component in signalling transduction pathways. It is found that many surface receptors rely on the tethering of cytoplasmic kinase to initiate and integrate signalling. A key factor to such reaction is the molecular reach; however, the role of it is incompletely understood. To date, a large number of compartment-based ODE and stochastic models have been developed to study this problem. In recent years, spatial-stochastic models have emerged as a more realistic representation for such processes, among which lattice-based stochastic reaction-diffusion models are a popular approach for studying complex spatio-temporal processes inside cells. To understand the role of molecular reach in tethered signalling, we employed an accurate and convergent lattice-based stochastic reaction-diffusion model (CRDME). We find that the molecular reach can increase or decrease biochemical reactions depending on the diffusion coefficient in 2D membrane but not in 3D cytosol.

Primary authors

Dr Ying Zhang (Boston University) Prof. Samuel Isaacson (Boston University) Prof. Omer Dushek (University of Oxford)

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