Bistable dynamics in a model of SIV infection with antibody response

11 Jul 2018, 11:50
New Law School/--020 (University of Sydney)

New Law School/--020

University of Sydney

Oral Presentation Disease - infectious In-host infections, HIV, immunity


Prof. Jonathan Forde (Hobart and William Smith Colleges)


Experiments in rhesus macaques have shown that for simian immunodeficiency virus the size of the viral inoculum and the infection stage of the donor animal alter the likelihood of establishment of infection. In this study, we postulate a role for the host and donor antibodies in explaining the dependence of infectiousness on donor infection stage. The resulting mathematical model exhibits bistable dynamics, with viral clearance and persistence dependent on initial conditions. We fit the model to temporal virus data using a censored data approach for measurements below the limit of detection, and make predictions about the minimal viral load in the inoculum required for persistent infection.

Primary author

Prof. Jonathan Forde (Hobart and William Smith Colleges)


Prof. Stanca Ciupe (Virginia Tech) Dr Christopher Miller (University of California, Davis)

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