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SUMMARY:The remarkable simplicity of complex signalling networks
DTSTART;VALUE=DATE-TIME:20180709T015000Z
DTEND;VALUE=DATE-TIME:20180709T021000Z
DTSTAMP;VALUE=DATE-TIME:20210228T010522Z
UID:indico-contribution-306@conferences.maths.unsw.edu.au
DESCRIPTION:Speakers: Robyn Araujo ()\nRobustness\, and the ability to fun
 ction and thrive amid changing and unfavourable environments\, is a fundam
 ental requirement for all living systems.  Moreover\, it has been a long-s
 tanding mystery how the extraordinarily complex communication networks ins
 ide living cells\, comprising thousands of different interacting molecules
 \, are able to exhibit such remarkable robustness since complexity is gene
 rally associated with fragility.  In this talk I will give an overview of 
 our recent research on robustness in cellular signalling networks\, with a
 n emphasis on the robust functionality known as Robust Perfect Adaptation 
 (RPA).  Our work has now suggested a resolution to the complexity-robustne
 ss paradox through the discovery that robust adaptive signalling networks 
 must be decomposable into topological basis modules of just two possible t
 ypes.  This newly-discovered modularisation of complex bionetworks has imp
 ortant implications for evolutionary biology\, embryology and development\
 , cancer research and drug development.\n\nhttps://conferences.maths.unsw.
 edu.au/event/2/contributions/306/
LOCATION:University of Sydney New Law School/--022
URL:https://conferences.maths.unsw.edu.au/event/2/contributions/306/
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