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SUMMARY:The bone ecosystem
DTSTART;VALUE=DATE-TIME:20180710T010000Z
DTEND;VALUE=DATE-TIME:20180710T013000Z
DTSTAMP;VALUE=DATE-TIME:20210228T011543Z
UID:indico-contribution-43@conferences.maths.unsw.edu.au
DESCRIPTION:Speakers: David Basanta (H. Lee Moffitt Cancer Center)\nSevera
 l types of cancer initiate or metastasize to the bone. These include the m
 ost prevalent and lethal cancers: lung\, breast and prostate. Thus underst
 anding the bone ecosystem is key if we want to predict what phenotypes wil
 l successfully metastasize to the bone and the subsequent evolutionary dyn
 amics that will ensue as the invading tumour cells learn how to co-opt the
  bone resident cells. This bone ecosystem is very dynamic and responds and
  maintains homeostasis as micro and macro fractures appear. A variety of h
 omeostatic processes emerge from the interactions of a myriad of cell type
 s and signalling factors. Here I will present mathematical models\, biolog
 ically motivated and tested\, that explain bone repair and homeostasis and
  allow us to explore how tumours can grow in the bone as well as the impac
 t of a variety of treatments not only on the tumour cells but also on the 
 bone ecosystem.\n\nhttps://conferences.maths.unsw.edu.au/event/2/contribut
 ions/43/
LOCATION:University of Sydney New Law School/--105
URL:https://conferences.maths.unsw.edu.au/event/2/contributions/43/
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