Dynamical conditions for the containment of HIV infection by CD8+ T Cells – a variable structure control approach

11 Jul. 2018, 11:30 am
30m
New Law School---024 (University of Sydney)

New Law School---024

University of Sydney

100
Oral Presentation Minisymposium: Modelling immune interactions with disease Modelling immune interactions with disease

Speaker

Dr Anet Jorim Norbert Anelone (Theoretical biology, Utrecht University)

Description

In the study of the Human Immunodeficiency Virus (HIV) infection dynamics, the reproductive ratio is a well known tool which provides a steady-state condition to determine the outcome of the infection. This paper assesses the control of HIV by the immune response. Dynamical conditions for the containment of HIV infection by the HIV-specific CD8+ T cell response are evaluated using a model of HIV dynamics in vivo in which HIV-infected cells are killed before they start producing new virion. The reachability paradigm from Variable Structure Control (VSC) theory is used to formulate a dynamical condition for immunity. Simulation results show that this reachability condition effectively monitors the immunological requirements to contain HIV. This work also suggests that the cytolytic killing mechanism of CD8+ T cells operates as a boundary layer control to contain HIV infection. Together, the findings indicate that in contrast to the reproductive ratio, the proposed VSC approach delivers a framework to assess the effects of nonlinear dynamics and uncertainty as well as providing a means to investigate immunotherapy strategies.

Primary authors

Dr Anet Jorim Norbert Anelone (Theoretical biology, Utrecht University) Sarah Spurgeon (University College London)

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