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SUMMARY:Dynamical conditions for the containment of HIV infection by CD8+ 
 T Cells – a variable structure control approach
DTSTART;VALUE=DATE-TIME:20180711T013000Z
DTEND;VALUE=DATE-TIME:20180711T020000Z
DTSTAMP;VALUE=DATE-TIME:20210228T005909Z
UID:indico-contribution-50@conferences.maths.unsw.edu.au
DESCRIPTION:Speakers: Anet Jorim Norbert Anelone (Theoretical biology\, Ut
 recht University)\nIn the study of the Human Immunodeficiency Virus (HIV) 
 infection dynamics\, the reproductive ratio is a well known tool which pro
 vides a steady-state condition to determine the outcome of the infection. 
 This paper assesses the control of HIV by the immune response. Dynamical c
 onditions for the containment of HIV infection by the HIV-specific CD8+ T 
 cell response are evaluated using a model of HIV dynamics in vivo in which
  HIV-infected cells are killed before they start producing new virion. The
  reachability paradigm from Variable Structure Control (VSC) theory is use
 d to formulate a dynamical condition for immunity. Simulation results show
  that this reachability condition effectively monitors the immunological r
 equirements to contain HIV. This work also suggests that the cytolytic kil
 ling mechanism of CD8+ T cells operates as a boundary layer control to con
 tain HIV infection. Together\, the findings indicate that in contrast to t
 he reproductive ratio\, the proposed VSC approach delivers a framework to 
 assess the effects of nonlinear dynamics and uncertainty as well as provid
 ing a means to investigate immunotherapy strategies.\n\nhttps://conference
 s.maths.unsw.edu.au/event/2/contributions/50/
LOCATION:University of Sydney New Law School/--024
URL:https://conferences.maths.unsw.edu.au/event/2/contributions/50/
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