Analysis of high-frequency telemetry data using machine learning enables differentiation of stages of $\textit{Plasmodium knowlesi}$ infections in non-human primates

11 Jul 2018, 16:00
New Law School/--102 (University of Sydney)

New Law School/--102

University of Sydney

Oral Presentation Minisymposium: Mathematical modelling of malaria: Dynamics within-host and between-hosts Mathematical modelling of malaria: Dynamics within-host and between-hosts


Mr Zerotti Woods (The University of Georgia)


High-frequency physiological data poses unique challenges for signal processing and computational analysis. This dataset was obtained from a cohort of Macaca mulatta and Macaca fascicularis infected with Plasmodium knowlesi using a customized telemetry system. The data set is comprised of electrocardiogram signals collected at a sampling rate of 1 kHz, temperature measures collected at 1 Hz, accelerometer data collected at 10 Hz, and blood pressure readings collected at 500 Hz. The implanted telemetry devices allowed nearly uninterrupted time series data acquisition over the course of an infection experiment. Machine learning algorithms using daily features were used to accurately classify a day of telemetry data between pre-infection and liver stage over 90% of the time. The experimental design, analysis, and framework used to address challenges in multi-scale telemetry signal processing will be discussed.

Primary authors

Mr Zerotti Woods (The University of Georgia) Mrs Jessica Brady (The University of Georgia) Mrs Elizabeth Trippe (The University of Georgia) Mr Diego Moncada Giraldo (The University of Georgia) Dr Chester Joyner (Emory University) Dr Jianlin Jiang (Emory University) Ms Monica Cabrera-Mora (Emory University) Ms Allison Hankus (Emory University) Dr Ebru Karpuzoglu (Emory University) Jennifer Wood (Emory University ) Mr Jay Humphrey (The University of Georgia) Mr Mustafa Nural (The University of Georgia) Dr Jeremy DeBarry (The University of Georgia) Dr Rabindra Tirouvanziam (Emory Universty) Dr Alberto Moreno (Emory University) Dr Jessica Kissinger (The University of Georgia) Dr Mary Galinski (Emory University) Dr Juan Gutierrez (The University of Georgia)

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