Conveners
Modelling feedback-mediated flow dynamics
- Brendan Fry (Metropolitan State University of Denver)
- Hwayeon Ryu (University of Hartford)
Description
Various feedback mechanisms allow different organ systems to maintain homeostasis, and to properly adjust flows in response to changing conditions. This occurs not just with blood flow, but also many other fluids in the body, including the tubular fluid of the kidney nephron. Complex interactions among different mechanisms make solely experimental approaches to studying feedback insufficient; as such, mathematical modelling approaches are a necessary supplement, allowing researchers to simulate processes that cannot be individually modulated in a lab.
This minisymposium will bring together researchers using mathematical modelling to address problems involving feedback-mediated flow dynamics in various tissues, including the kidney, eye, and brain. The goal will be to expose the different modelling techniques used to describe feedback-mediated flow in these different circumstances, and determine if there are techniques being used in one area that could be used for others. Such overlapping modelling strategies will promote collaboration, and help advance research into the mechanisms underlying feedback-mediated flow dynamics in a variety of tissues.
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The kidney plays an essential role in regulating the blood pressure and a number of its func- tions operate at the functional unit of the kidney, the nephron. To understand the impacts of internephron coupling on the overall nephrons’ dynamics, we develop a mathematical model of a tubuloglomerular feedback (TGF) system, a negative feedback mechanism for nephron’s fluid capacity. Specifically,...
Background and Purpose: Renal hypoxia is postulated to be a leading cause of acute kidney injury, and the renal medulla is known to be most susceptible to hypoxia. The ability to accurately predict normal and abnormal oxygen states in terms of tissue oxygen tension (PO2) within the renal medulla is highly desirable, as among other uses predicted medullary PO2 can be correlated with local...
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