Conveners
Mathematical modelling of malaria: Dynamics within-host and between-hosts
- Kyle Dahlin (Purdue University)
- Lauren Childs ()
Description
Malaria is a mosquito-borne disease caused by infection with Plasmodium parasites. Despite concerted efforts to end malaria transmission, there continue to be over 200 million new cases of malaria each year, of which several hundred thousand result in death. Mathematical modelling provides methods to determine transmission mechanisms and evaluate effective forms of control. Recently, there has been a greater focus on connecting models of the progression of malaria within hosts (immunology) with transmission models of infection between hosts (epidemiology). These two perspectives and their interface are necessary in the pursuit of malaria elimination. In this session, there will be talks spanning the scales of malaria dynamics from within-host to between-host.
In this seminar, I will present the results obtained from investigating the optimal control strategies for malaria in the presence of temperature variation using a temperature dependent malaria model. A 2015 study by Agusto et al. identified the suitable temperature ranges for mosquitoes in four different geographical regions of Sub-Saharan Africa as [22.61$\rm^o$C - 28.58$\rm^o$C] in West...
Falciparum malaria is a major parasitic disease causing widespread morbidity and mortality globally. Artemisinin derivatives – the most effective and widely-used antimalarials that have helped reduce the burden of malaria by 60% in some areas over the past decade – have recently been found to induce growth retardation of blood-stage Plasmodium falciparum when applied at clinically relevant...
High-frequency physiological data poses unique challenges for signal processing and computational analysis. This dataset was obtained from a cohort of Macaca mulatta and Macaca fascicularis infected with Plasmodium knowlesi using a customized telemetry system. The data set is comprised of electrocardiogram signals collected at a sampling rate of 1 kHz, temperature measures collected at 1...
Over the last decade, control measures have significantly reduced malaria morbidity and mortality. However, the burden of malaria remains high, with more than 70% of malaria deaths occurring in children under the age of five. The spread of antimalarial resistant parasites challenges the efficacy of current interventions, such as Intermittent Preventive Treatment (IPT), whose aim it is to...
