Multiscale modelling of sleep and circadian systems

12 Jul 2018, 10:30
New Law School/--026 (University of Sydney)

New Law School/--026

University of Sydney



Multiscale modelling of sleep and circadian systems: Part A

  • Andrew Phillips (Monash University)
  • Svetlana Postnova (University of Sydney)
  • Gen Kurosawa ()

Multiscale modelling of sleep and circadian systems: Part B

  • Svetlana Postnova (University of Sydney)
  • Andrew Phillips (Monash University)
  • Gen Kurosawa ()


We spend 1/3 of our life asleep but the mechanisms and purpose of sleep are yet to be fully elucidated. Sleep is essential for healthy physiological function, and its lack leads to increased sleepiness and disease. The daily sleep-wake cycles are controlled by the endogenous circadian (~24 hour) clocks in the brain and the body, which are also responsible for biological rhythms of other functions including metabolism, immunity, and neurodegeneration. The circadian clocks are adjusted by environmental and behavioural time cues; e.g., the light/dark cycle for entrainment of the central circadian clock in the brain. A correct alignment between these time cues, circadian clocks, and behaviour is essential for optimal physiological function. The complex biological systems controlling the circadian clocks and sleep span multiple temporal and spatial scales: from genetic feedback loops and cellular interaction to brain dynamics and physiological functions. This minisymposium will focus on quantitative physiologically based modelling of sleep and circadian clocks at these different scales to reveal the key mechanisms underpinning dynamics of the biological systems involved and to highlight the importance of mathematical and physical research across the different temporal and spatial scales.

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