Conveners
Multistrain models & resistance
- Rebecca Chisholm (University of Melbourne)
Environmental fluctuations, such as those caused by seasonality, are common, and climate change is expected to increase the amplitude of environmental oscillations. Therefore it is important to understand how increasing the amplitude of environmental oscillations will affect evolutionary processes, and in particular host-parasite evolution, where the extent of evolution is likely to be...
As dengue is one of the human diseases with global concern, the host-vector shuttle and the bottleneck of dengue transmission is a significant aspect to study. For the four serotypes of dengue virus within host and their transmission to the vectors, we try to capture the variability in blood viremia and antibody levels of patients and their infectiousness to mosquitoes. The present model...
The growing threat of antimicrobial drug resistance presents a significant challenge not only to the medical community, but the wider general population. Alarmingly, resistant strains of infectious diseases are already endemic in many communities – particularly in developing countries and lower socio-economic settings – with new strains, which enjoy even more extensive resistance, continually...
Infectious diseases undergo evolutionary changes as they spread and persist in populations. Different diseases present substantially different evolutionary dynamics, with both large-scale changes that create different strains, or more incremental shifts within a strain. In this talk, we demonstrate how a general stochastic epidemic model can be used to explain different types of evolutionary...
Over the last years, a number of stochastic models have been proposed for analysing the spread of nosocomial infections in hospital settings. These models often account for a number of factors governing the spread dynamics: spontaneous patient colonization, patient-staff contamination/colonization, environmental contamination, patient cohorting, or health-care workers (HCWs) hand-washing...
Antibiotic resistance has become one of the major health issues in the world. It kills around 700,000 people each year worldwide, and will become even worse if no new antibiotics are developed (Nature, 2017). Therefore, serious efforts are required to prevent more severe conditions in the future. One important effort in this case is understanding the dynamics of the problem so that effective...