Conveners
In-host, cell cycle & differentiation
- Veronica Ciocanel (Mathematical Biosciences Institute at The Ohio State University)
Acute graft-versus-host disease (aGVHD) is the major complication of Allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT). A lot of previous studies showed that the importance of DNAM-1(CD226) which is expressed on CD4+ T cells, CD8+ T cells, natural killer (NK) cells, and monocytes Therefore, DNAM-1 has been considered as essential molecule of developing aGVHD in vitro and vivo...
During differentiation process, cell type specific gene expression pattern is established by orchestrate regulatory network of transcription factors (TFs). Resolving the structure of the transcriptional regulatory network (TRN) is promising way to understand the detailed mechanism of cell differentiation.
Here I estimate a transcriptional regulatory network determining the cell type specific...
Binary genetic switches are widely used in synthetic biology for switching between two expression states, ON and OFF. In particular, single input switches, which alternate between ON and OFF in response to the same input signals, are the key elements of counting devices which count the occurrence of a repeated intracellular or extracellular signal. Most existing DNA switches require two...
Fluorescent ubiquitination-based cell cycle indicator, also known as FUCCI, allows the visualisation of the G1 and S/G2/M cell cycle phases of individual cells. FUCCI consists of two fluorescent probes, so that cells in the G1 phase fluoresce red and cells in the S/G2/M phase fluoresce green. FUCCI reveals real-time information about cell cycle dynamics of individual cells, and can be used to...
Typically, discrete stochastic models of cell proliferation use a rate to determine whether or not a cell proliferates at a particular time, producing an exponential distribution for the time between proliferation events. Actual experiments, however, suggest that cells actually have a Gaussian distribution in their time to proliferate, with a relatively small standard deviation. This talk will...