Conveners
Fluids & blood
- Anne Talkington ()
Monitoring the fluid status of end-stage renal disease (ESRD) patients remains an important aspect in hemodialysis. Recently, de los Reyes et al. developed a two-compartment model describing vascular refilling with ultrafiltration during short-term hemodialysis in ESRD patients. Ultrafiltration is taking out fluid from the vascular space; and vascular refilling occurs through the...
Blood clots are physiologically degraded via a biochemical cascade initiated by tissue plasminogen activator (tPA). tPA, which is also used clinically to treat stroke, creates plasmin, the main protein involved in degradation. We explore the effects of tPA unbinding and diffusion on clot degradation. We propose that plasmin can “force” tPA to unbind from the clot, which has significant...
The Endothelial Glycocalyx Layer (EGL) is a porous macromolecular layer that lines the insides of blood vessels. It is located on the important interface between the endothelium and flowing blood and as such is believed to play a number of important roles including transducing mechanical signals from flowing blood and regulating vessel permeability. Previous work modelling the EGL at the...
