BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//CERN//INDICO//EN
BEGIN:VEVENT
SUMMARY:Modelling for Dye-Sensitized Solar Cells with a Fractional Derivat
ive
DTSTART;VALUE=DATE-TIME:20191125T051000Z
DTEND;VALUE=DATE-TIME:20191125T052500Z
DTSTAMP;VALUE=DATE-TIME:20230607T050004Z
UID:indico-contribution-4-506@conferences.maths.unsw.edu.au
DESCRIPTION:Speakers: Benjamin Maldon (University of Newcastle)\nDye-Sensi
tized Solar Cells (DSSCs) play a vital role in renewable energy as a third
-generation photovoltaic device. The efficiency and current-voltage charac
ters of a typical DSSC are usually derived from the density of conduction
band electrons within the nanoporous semiconductor of the DSSC. Given the
known fractal geometry of the commonly used semiconductor Titanium Dioxide
($\\text{TiO}_2$)\, a natural direction for mathematically modelling DSSC
s uses fractional diffusion. With Caputo fractional derivatives on time an
d space we solve this fractional diffusion equation analytically and numer
ically to investigate the effect of the fractional derivative on the diffu
sion process in an operating DSSC.\n\nhttps://conferences.maths.unsw.edu.a
u/event/4/contributions/506/
LOCATION:Kirby Institute\, UNSW Sydney Wallace Wurth-6-638 - Seminar Room
URL:https://conferences.maths.unsw.edu.au/event/4/contributions/506/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Optimal energy configurations of coronene molecules inside carbon
nanotubes
DTSTART;VALUE=DATE-TIME:20191125T010000Z
DTEND;VALUE=DATE-TIME:20191125T011500Z
DTSTAMP;VALUE=DATE-TIME:20230607T050004Z
UID:indico-contribution-4-517@conferences.maths.unsw.edu.au
DESCRIPTION:Speakers: Kyle Stevens (University of Newcastle)\nThe producti
on of one-dimensional carbon structures has recently been made easier by u
sing carbon nanotubes. Here\, we consider encapsulated coronene molecules
inside carbon nanotubes. Coronene is a flat\, circular-shaped polycyclic a
romatic hydrocarbon. Depending on the radius of the nanotube\, specific co
nfiguration of the coronene molecules can be achieved\, giving rise to the
formation of stacked columns or aid in forming nanoribbons. Due to its sy
mmetrical structure\, we assume that a coronene molecule comprises three i
nner circular rings of carbon atoms and one outer circular ring of hydroge
n atoms. Using a continuum approach and the Lennard-Jones potential\, we o
btain the interaction energy between the nanotube and the coronene molecul
e. Minimising this energy\, we obtain a range of nanotube radii that give
rise to particular configurations of a coronene molecule\, including tilte
d\, perpendicular to the nanotube’s axis and lying flat on the nanotube
’s axis. We also extend this model to consider a stack of coronene molec
ules inside a nanotube. Finally\, we compare our analytical results with m
olecular dynamics simulations as well as briefly discuss an alternative ap
proach to model coronene using a flat disk instead of a combination of rin
gs.\n\nhttps://conferences.maths.unsw.edu.au/event/4/contributions/517/
LOCATION:Kirby Institute\, UNSW Sydney Wallace Wurth-6-638 - Seminar Room
URL:https://conferences.maths.unsw.edu.au/event/4/contributions/517/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Statistical modelling to optimize the design of HIV latency studie
s
DTSTART;VALUE=DATE-TIME:20191124T220500Z
DTEND;VALUE=DATE-TIME:20191124T224500Z
DTSTAMP;VALUE=DATE-TIME:20230607T050004Z
UID:indico-contribution-4-526@conferences.maths.unsw.edu.au
DESCRIPTION:Speakers: Timothy Schlub (University of Sydney)\nA cure for HI
V is prevented by the very small population of “latently” infected cel
ls that persist despite treatment. Experimental and ethical challenges stu
dying this cellular population result in few HIV infected recruits per stu
dy. Consequently\, the analysis of such data presents several challenges i
ncluding limited by statistical power\, correlated errors and data with un
defined error distributes. We use statistical modelling strategies to over
come these challenges and find that a limiting factor in many study design
s is the high across participant variability\; and limited number of cells
available for collection per participant. We use power and sample size es
timation to explore how these limiting factors need to be balanced to opti
mize future study designs in HIV latency.\n\nhttps://conferences.maths.uns
w.edu.au/event/4/contributions/526/
LOCATION:Kirby Institute\, UNSW Sydney Wallace Wurth-6-638 - Seminar Room
URL:https://conferences.maths.unsw.edu.au/event/4/contributions/526/
END:VEVENT
BEGIN:VEVENT
SUMMARY:The potential role of a reaction-diffusion system in the establish
ment and maintenance of neuronal polarity
DTSTART;VALUE=DATE-TIME:20191125T003000Z
DTEND;VALUE=DATE-TIME:20191125T004500Z
DTSTAMP;VALUE=DATE-TIME:20230607T050004Z
UID:indico-contribution-4-519@conferences.maths.unsw.edu.au
DESCRIPTION:Speakers: Zhuang Xu ()\nNeuronal polarity is critical for prop
er functioning of neurons. There is a lot of experimental evidence suggest
ing that the early establishment of this polarity is a dynamical event. On
e potential mechanism for achieving this polarity is via Turing patterns\,
where non-linear molecular interactions spontaneously produce spatiotempo
ral concentration gradients. Linear instability analysis of reaction-diffu
sion systems shows that the pattern formed should generally correspond to
eigenfunctions of the Laplace-Beltrami operator. In this work\, we develop
a numerical method to efficiently approximate Laplace-Beltrami operator o
ver the geometry of a neuron. We then compare the Laplacian eigenfunctions
with the concentration profile of fluorophore labels extracted from the f
luorescence micrographs of early developing hippocampal neurons (\n\nhttps
://conferences.maths.unsw.edu.au/event/4/contributions/519/
LOCATION:Kirby Institute\, UNSW Sydney Wallace Wurth-6-638 - Seminar Room
URL:https://conferences.maths.unsw.edu.au/event/4/contributions/519/
END:VEVENT
BEGIN:VEVENT
SUMMARY:The effect of ambient temperature oscillations have on the critica
l ignition criteria
DTSTART;VALUE=DATE-TIME:20191125T004500Z
DTEND;VALUE=DATE-TIME:20191125T010000Z
DTSTAMP;VALUE=DATE-TIME:20230607T050004Z
UID:indico-contribution-4-513@conferences.maths.unsw.edu.au
DESCRIPTION:Speakers: Matthew Berry ()\nThe effect of ambient temperature
oscillations on the critical ignition criteria for large stockpiles underg
oing self-heating is investigated.\n A two dimension reaction-diffusion
model is examined on a rectangular domain subject to sinusoidal variation
of ambient temperature. The parameters for the temperature variation is on
data obtained for the Port Kembla region. The oscillatory behaviour appro
ximates yearly fluctuations around the mean temperature\, diurnal fluctuat
ions are not included. The control parameter for bifurcation analysis is t
he ratio of the length of the stockpile to its height.\n This work is mot
ivated by the self-sintering of steel by-products in stockpiles. In this a
pplication high temperatures due to self-heating are desirable as the resu
lting product has improved physical properties which make it easier to rec
ycle on site.\n\nhttps://conferences.maths.unsw.edu.au/event/4/contributio
ns/513/
LOCATION:Kirby Institute\, UNSW Sydney Wallace Wurth-6-638 - Seminar Room
URL:https://conferences.maths.unsw.edu.au/event/4/contributions/513/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Nonisothermal Film Blowing: Precursor Results & Modeling
DTSTART;VALUE=DATE-TIME:20191125T011500Z
DTEND;VALUE=DATE-TIME:20191125T013000Z
DTSTAMP;VALUE=DATE-TIME:20230607T050004Z
UID:indico-contribution-4-508@conferences.maths.unsw.edu.au
DESCRIPTION:Speakers: Marcia Ricci Pinheiro (IICSE University )\nThe resul
ts come from work done in 2002\; Pinheiro's thesis for an MSci in Mathemat
ics from 2003 done in exchange for a Vice Chancellor's grant. It was the f
irst description of the Bubble Problem\, which deals with plastic film for
mation\, that involved exclusively Mathematics. The work was a development
from the work of Tam\, a Master's thesis from 2002\, RMIT. Refinements on
scaling\, and description\, thanks to how practical the problem is\, allo
wed for much simpler calculations\, and simulations in the computer using
Maple led to confirmation of the results. This talk also brings some initi
al theory on how to avoid mistakes when modelling real-life situations.\n\
nhttps://conferences.maths.unsw.edu.au/event/4/contributions/508/
LOCATION:Kirby Institute\, UNSW Sydney Wallace Wurth-6-638 - Seminar Room
URL:https://conferences.maths.unsw.edu.au/event/4/contributions/508/
END:VEVENT
BEGIN:VEVENT
SUMMARY:A Framework for Analysing Localised Patterns and the Narrow Escape
Problem on Curved Surfaces
DTSTART;VALUE=DATE-TIME:20191124T235000Z
DTEND;VALUE=DATE-TIME:20191125T003000Z
DTSTAMP;VALUE=DATE-TIME:20230607T050004Z
UID:indico-contribution-4-521@conferences.maths.unsw.edu.au
DESCRIPTION:Speakers: Justin Tzou ()\nFor the Schnakenberg activator-inhib
itor model\, in the singularly perturbed regime of small activator to inhi
bitor diffusivity ratio $\\varepsilon^2 \\ll 1$\, we demonstrate the analy
tic-numerical computation of the dynamics and stability thresholds of loca
lized spot patterns on a curved torus. By way of a hybrid asymptotic-numer
ical analysis\, we obtain the results in terms of certain quantities assoc
iated with the Green's function for both the Laplace-Beltrami ($\\Delta_g$
) and Helmholtz ($\\Delta_g - V$) operators on the torus. To this end\, we
introduce a new analytic-numerical method for computing Green's functions
on surfaces that requires only the numerical solution of a problem that i
s as regular as is desired. This allows properties of Green's functions at
the location of the singularity to be determined to a high degree of accu
racy. We will then describe how the solution of this problem also leads di
rectly to a framework for analysing the narrow escape problem on curved su
rfaces.\n\nhttps://conferences.maths.unsw.edu.au/event/4/contributions/521
/
LOCATION:Kirby Institute\, UNSW Sydney Wallace Wurth-6-638 - Seminar Room
URL:https://conferences.maths.unsw.edu.au/event/4/contributions/521/
END:VEVENT
BEGIN:VEVENT
SUMMARY:A dynamic model of human immunodeficiency virus and human papillom
avirus interaction
DTSTART;VALUE=DATE-TIME:20191124T231500Z
DTEND;VALUE=DATE-TIME:20191124T233000Z
DTSTAMP;VALUE=DATE-TIME:20230607T050004Z
UID:indico-contribution-4-510@conferences.maths.unsw.edu.au
DESCRIPTION:Speakers: Michaela Hall (School of Mathematics and Statistics\
, UNSW)\nThe transmission\, progression and treatment of human immunodefic
iency virus (HIV) can have unexpected effects on the acquisition and progr
ession of human papillomavirus (HPV) in co-infected patients. HPV is the c
ausative agent of cervical cancer\, which is a leading cause of cancer dea
th among women in the developing world. We have developed a dynamic model
of HIV and HPV co-infection\, accounting for a range of demographic and be
havioural factors with the aim of assessing the impact of the HIV epidemic
on HPV and cervical cancer in Tanzania. The model has been calibrated usi
ng epidemic data local to Tanzania and has been subjected to extensive val
idation and sensitivity analysis. Findings from this analysis suggest that
in the near-term\, effective HIV treatment and prevention will increase r
ates of cervical cancer in Tanzanian women due to the removal of HIV-death
as a competing risk. However\, in the long-term HIV treatment is predicte
d to reduce rates of cervical cancer\, due to reconstitution of the immune
system delaying progression from HPV infection to cervical cancer. These
findings are useful for predicting epidemic trends and assessing the unexp
ected impacts of interventions\, which can be used to guide future healthc
are policy and investment decisions.\n\nhttps://conferences.maths.unsw.edu
.au/event/4/contributions/510/
LOCATION:Kirby Institute\, UNSW Sydney Wallace Wurth-6-638 - Seminar Room
URL:https://conferences.maths.unsw.edu.au/event/4/contributions/510/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Impact of fluctuation in frequency of HIV / SIV reactivation durin
g antiretroviral therapy interruption
DTSTART;VALUE=DATE-TIME:20191124T230000Z
DTEND;VALUE=DATE-TIME:20191124T231500Z
DTSTAMP;VALUE=DATE-TIME:20230607T050004Z
UID:indico-contribution-4-515@conferences.maths.unsw.edu.au
DESCRIPTION:Speakers: Yuhuang Wu (The Kirby Institute\, University of New
South Wales)\nAntiretroviral Therapy (ART) provides effective control of h
uman immunodeficiency virus (HIV) replication and maintains the viral load
s of HIV at undetectable levels. Interruption of ART causes recrudescence
of HIV plasma viremia due to the reactivation of latently HIV-infected cel
ls\, generally within weeks of discontinuation of ART. Here we characteriz
e the timing of both the initial and subsequent successful viral reactivat
ions following ART interruption in macaques infected with simian immunodef
iciency virus (SIV). We compare these to previous results from human patie
nts infected with HIV. We find that on average the time until the first su
ccessful viral reactivation event is longer than the time between subseque
nt successful reactivations. Based on this result\, we hypothesise that th
e reactivation frequency of both HIV and SIV may fluctuate over time and t
hat this may have implications for treatment of HIV. We develop a stochast
ic model to simulate the behaviour of viral reactivation following ART int
erruption that incorporates fluctuations in the frequency of reactivation.
Our model is able to explain the difference in timing between the initial
and subsequent successful reactivation events. Furthermore\, we show that
one of the impacts of a fluctuating reactivation frequency would be to si
gnificantly reduce the efficacy of “anti-latency” interventions for HI
V that aim to reduce the frequency of reactivation. It is therefore essent
ial to consider the possibility of a fluctuating reactivation frequency wh
en assessing the impact of such intervention strategies.\n\nhttps://confer
ences.maths.unsw.edu.au/event/4/contributions/515/
LOCATION:Kirby Institute\, UNSW Sydney Wallace Wurth-6-638 - Seminar Room
URL:https://conferences.maths.unsw.edu.au/event/4/contributions/515/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Early events in transmission and infection of Simian Immunodeficie
ncy Virus
DTSTART;VALUE=DATE-TIME:20191124T224500Z
DTEND;VALUE=DATE-TIME:20191124T230000Z
DTSTAMP;VALUE=DATE-TIME:20230607T050004Z
UID:indico-contribution-4-511@conferences.maths.unsw.edu.au
DESCRIPTION:Speakers: Steffen Docken (The Kirby Institute\, UNSW)\nThe HIV
epidemic remains a massive burden on global health\, and as a result\, a
great deal of resources have been invested into developing an effective va
ccine or cure that does not require life-long treatment. One of the funda
mental questions that must be answered in order to evaluate potential vacc
ines is how effective must a vaccine be at blocking HIV replication in ord
er to prevent infection following exposure? The ability of a virus such a
s HIV to grow and persist within an individual is dependent on the average
number of subsequently infected cells resulting from viruses released fro
m a single infected cell\, also known as the Basic Reproductive Number or
$R_0$ (similar to $R_0$ in epidemiology). A vaccine must lower $R_0$ to b
elow 1 in order to prevent the infection from growing following exposure\,
and therefore the how effective a vaccine must be at blocking HIV replica
tion is dependent on the underlying $R_0$ of HIV. As $R_0$ cannot be meas
ured directly\, $R_0$ has been estimated based on the observed growth of v
irus within people living with HIV or animals infected with the related si
mian immunodeficiency virus (SIV). However\, such estimates of $R_0$ are
heavily dependent on assumptions made about the replication cycle of HIV\,
such as the time interval from when a cell is infected to when the cell r
eleases newly produced virus. In order to develop an effective\, long-ter
m cure for HIV\, we need to better understand the dynamics of the infectio
n. \nTo better understand the HIV replication cycle and therefore better
determine what is needed of an effective vaccine\, collaborators developed
a barcoded SIV virus\, which allows us to track the progress within an an
imal of multiple infections all initiated by a single virion. We observe
a high degree of variability in the early stages of infection\, with blood
concentrations of different barcoded viruses varying by over four orders
of magnitude. We demonstrate that this variability in fact arises from st
ochasticity in the processes of SIV replication\, such as the time to vira
l production following infection. Finally\, we examine how variability in
time to viral production affects our estimate for $R_0$\, thereby adjusti
ng our expectation for the required efficacy of potential vaccines and cur
ative therapies.\n\nhttps://conferences.maths.unsw.edu.au/event/4/contribu
tions/511/
LOCATION:Kirby Institute\, UNSW Sydney Wallace Wurth-6-638 - Seminar Room
URL:https://conferences.maths.unsw.edu.au/event/4/contributions/511/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Modelling the Immune Response of CD4+ T cells: An intimate relatio
nship between T cells and APCs
DTSTART;VALUE=DATE-TIME:20191125T030500Z
DTEND;VALUE=DATE-TIME:20191125T032000Z
DTSTAMP;VALUE=DATE-TIME:20230607T050004Z
UID:indico-contribution-4-516@conferences.maths.unsw.edu.au
DESCRIPTION:Speakers: Pantea Pooladvand (University of Sydney)\nThe clonal
expansion of T cells during an infection is a tightly regulated event to
ensure an appropriate immune response is mounted against invading pathogen
s. Although experiments have mapped the dynamics of the response from expa
nsion to contraction\, the mechanisms which control this response are not
well defined. Here\, we propose a model in which the dynamics of T cell ex
pansion is ultimately controlled through continuous interactions between T
cells and antigen presenting cells. T cell clonal expansion is proportion
al to antigen availability and antigen availability is regulated through d
ownregulation of antigen by T cells. We show that our model can predict ov
erall T cell expansion\, recruitment into division and burst size per cell
. Importantly\, the findings demonstrates how an intimate relationship bet
ween T cells and APCs can explain the ability of the immune system to tail
or its response to dose of antigen\, regardless of initial T cell precurso
r frequencies.\n\nhttps://conferences.maths.unsw.edu.au/event/4/contributi
ons/516/
LOCATION:Kirby Institute\, UNSW Sydney Wallace Wurth-6-638 - Seminar Room
URL:https://conferences.maths.unsw.edu.au/event/4/contributions/516/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Closing remarks
DTSTART;VALUE=DATE-TIME:20191125T055500Z
DTEND;VALUE=DATE-TIME:20191125T060000Z
DTSTAMP;VALUE=DATE-TIME:20230607T050004Z
UID:indico-contribution-4-525@conferences.maths.unsw.edu.au
DESCRIPTION:https://conferences.maths.unsw.edu.au/event/4/contributions/52
5/
LOCATION:Kirby Institute\, UNSW Sydney Wallace Wurth-6-638 - Seminar Room
URL:https://conferences.maths.unsw.edu.au/event/4/contributions/525/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Modelling of swarming locusts with food distributions
DTSTART;VALUE=DATE-TIME:20191125T054000Z
DTEND;VALUE=DATE-TIME:20191125T055500Z
DTSTAMP;VALUE=DATE-TIME:20230607T050004Z
UID:indico-contribution-4-520@conferences.maths.unsw.edu.au
DESCRIPTION:Speakers: Fillipe Georgiou (UON)\nLocusts are short horned gra
sshoppers that exhibit two behaviour types depending on their local densit
y. These are\; solitary\, where they will actively avoid other locusts\, a
nd gregarious\, where they will actively seek them out. It is in this greg
arious state that locusts can form massive and destructive swarms or plagu
es. It is hypothesised that compact discrete food sources can lead to a gr
eater likelihood that these outbreaks will occur. By modifying a previous
gregarization model to include locust hunger and food interaction\, we wer
e able to test this hypothesis.\n\nhttps://conferences.maths.unsw.edu.au/e
vent/4/contributions/520/
LOCATION:Kirby Institute\, UNSW Sydney Wallace Wurth-6-638 - Seminar Room
URL:https://conferences.maths.unsw.edu.au/event/4/contributions/520/
END:VEVENT
BEGIN:VEVENT
SUMMARY:The population dynamics of ecosystem engineers and habitat modific
ation
DTSTART;VALUE=DATE-TIME:20191125T052500Z
DTEND;VALUE=DATE-TIME:20191125T054000Z
DTSTAMP;VALUE=DATE-TIME:20230607T050004Z
UID:indico-contribution-4-518@conferences.maths.unsw.edu.au
DESCRIPTION:Speakers: Rashed Saifuddin (UNSW Canberra)\nEcosystem engineer
s are species which invade an already occupied habitat with an existing re
sident species and "engineer" the habitat to better suit their needs and s
urvival. Although an obvious example would be the human species\, a better
example would be beavers\, which builds dams to protect themselves from p
redators and allow easy access to food during winter. We will present a or
dinary differential equation mathematical model to describe the state of t
he habitat and the population dynamics. The behaviour of the model will be
classified and the model\nextended to include stochastic and time delay e
ffects.\n\nhttps://conferences.maths.unsw.edu.au/event/4/contributions/518
/
LOCATION:Kirby Institute\, UNSW Sydney Wallace Wurth-6-638 - Seminar Room
URL:https://conferences.maths.unsw.edu.au/event/4/contributions/518/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Energy Selective Neutron Transmission Imaging at a Pulse Source
DTSTART;VALUE=DATE-TIME:20191125T045500Z
DTEND;VALUE=DATE-TIME:20191125T051000Z
DTSTAMP;VALUE=DATE-TIME:20230607T050004Z
UID:indico-contribution-4-509@conferences.maths.unsw.edu.au
DESCRIPTION:Speakers: Riya Riya Aggarwal ()\nWe are developing a tomograph
ic reconstruction algorithm for residual strain fields from Bragg-edge str
ain images. The Finite element approach is used to model a longitudinal ra
y transform which is expressed in terms of the same finite element mesh us
ed to model equilibrium within the system. This model is not based on the
usual structural finite element method where displacement is unknown. In o
ur case\, the elastic strain is unknown at the nodes. A linearly constrain
ed least-squares optimisation problem is used to find the solution.\n\nhtt
ps://conferences.maths.unsw.edu.au/event/4/contributions/509/
LOCATION:Kirby Institute\, UNSW Sydney Wallace Wurth-6-638 - Seminar Room
URL:https://conferences.maths.unsw.edu.au/event/4/contributions/509/
END:VEVENT
BEGIN:VEVENT
SUMMARY:A gradient recovery technique for virtual element methods
DTSTART;VALUE=DATE-TIME:20191125T044000Z
DTEND;VALUE=DATE-TIME:20191125T045500Z
DTSTAMP;VALUE=DATE-TIME:20230607T050004Z
UID:indico-contribution-4-507@conferences.maths.unsw.edu.au
DESCRIPTION:Speakers: Balaje Kalyanaraman (University of Newcastle\, Austr
alia)\nIn this talk\, I will present a gradient recovery technique based o
n an oblique projection for the virtual element method on polygonal meshes
. I will give a short introduction to the virtual element method and intro
duce the gradient recovery operator and its construction. Finally\, I will
present some numerical results showing the comparison between convergence
rates of the standard gradient and the recovered gradient.\n\nhttps://con
ferences.maths.unsw.edu.au/event/4/contributions/507/
LOCATION:Kirby Institute\, UNSW Sydney Wallace Wurth-6-638 - Seminar Room
URL:https://conferences.maths.unsw.edu.au/event/4/contributions/507/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Who carries malaria parasites over the dry season?
DTSTART;VALUE=DATE-TIME:20191125T033500Z
DTEND;VALUE=DATE-TIME:20191125T035000Z
DTSTAMP;VALUE=DATE-TIME:20230607T050004Z
UID:indico-contribution-4-512@conferences.maths.unsw.edu.au
DESCRIPTION:Speakers: Eva Stadler ()\nMalaria causes almost half a million
deaths every year. In particular\, malaria is common in areas with season
al variations in the transmission rate. During the dry season\, the number
of mosquitoes is very low\, there are few new infections\, and few clinic
al malaria cases. However\, shortly after the beginning of the rainy seaso
n both mosquitoes and malaria parasites become abundant. There is evidence
that some people carry the parasites over the dry season and humans thus
serve as a parasite reservoir. We consider a mathematical model in order t
o characterize these “carriers”. The model includes stochastic infecti
ous mosquito bites with the rate of bites depending on the season and dete
rministic within-host dynamics. Each infectious mosquito bite inoculates a
new parasite strain. For the within-host dynamics we consider parasite co
ncentration\, strain-specific immunity\, and general immunity. Simulations
indicate that children who are more exposed to mosquitoes and older child
ren have lower parasite multiplication rates\, i.e.\, their parasites grow
slower. Thus\, they have longer lasting infections and they can carry par
asites through the dry season.\n\nhttps://conferences.maths.unsw.edu.au/ev
ent/4/contributions/512/
LOCATION:Kirby Institute\, UNSW Sydney Wallace Wurth-6-638 - Seminar Room
URL:https://conferences.maths.unsw.edu.au/event/4/contributions/512/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Improving the method to assessing antimalarial drug efficacy
DTSTART;VALUE=DATE-TIME:20191125T032000Z
DTEND;VALUE=DATE-TIME:20191125T033500Z
DTSTAMP;VALUE=DATE-TIME:20230607T050004Z
UID:indico-contribution-4-514@conferences.maths.unsw.edu.au
DESCRIPTION:Speakers: Georges Radohery (Kirby Institute)\nMalaria is killi
ng one child every two minutes in some of the most vulnerable parts of the
word. The development of new antimalarial drug therapies has led to an es
sential reduction of malaria incidence and mortality rates for the past 15
years. But malaria also has a track record for developing resistance agai
nst its treatment\, and it is now once more developing resistance against
artemisinin\, its most effective treatment in south-east Asia. Therefore\,
we need to continue developing better drug therapies. A standard method
to assess drug efficacy is to look at how quickly parasites are removed fr
om patients blood after the treatment. This method assumes that parasites
remaining in the blood after the drug treatment are only alive parasites\,
and the drug killing rate is them thought to be equal to the parasites nu
mber decline rate. This standard method is imprecise because recently\, we
could estimate that dead parasites represent an important portion of circ
ulating parasites after a treatment. Therefore\, it is crucial to develop
a new method of drug efficacy assessment that takes into account these dea
d circulating parasites. \n\nTo do so\, we used data from ex-vivo cultures
to measure parasite viability after treatment. Then\, we used these para
site viability measurements to extend an existing within-host model of par
asites growth and drugs killing. This extended model allowed us to separat
ely measure the drug killing rate and the host removal rate of the dead pa
rasites. Hence\, our new model revealed artesunate killed parasite with a
0.3-hour half-life (95% CI: 0.2-h\, 0.5-h)\, which is tenfold faster than
the 3-hours estimate from the old measure. We then applied these approache
s to understanding artemisinin resistance. The modelling demonstrated that
parasites are much more resistant than is indicated by the standard metho
d of assessing drug killing. In conclusion\, more accurate models of drug
killing are possible\, and the malaria drug development pipeline urgently
needs to adopt a new approach to assessing drug efficacy.\n\nhttps://confe
rences.maths.unsw.edu.au/event/4/contributions/514/
LOCATION:Kirby Institute\, UNSW Sydney Wallace Wurth-6-638 - Seminar Room
URL:https://conferences.maths.unsw.edu.au/event/4/contributions/514/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Stock loans and their American connection
DTSTART;VALUE=DATE-TIME:20191125T022500Z
DTEND;VALUE=DATE-TIME:20191125T030500Z
DTSTAMP;VALUE=DATE-TIME:20230607T050004Z
UID:indico-contribution-4-522@conferences.maths.unsw.edu.au
DESCRIPTION:Speakers: Xiaoping Lu (University of Wollongong)\nA stock loan
is a financial derivative that allows the holder of stocks use them as co
llaterals for borrowing fund. Mathematically\, stock loans can be treated
as a special type of American call options. In this talk\, we will first
discuss the “American” connection between stock loans and options. The
n\, we shall discuss the valuation of stock loans as American options in t
he following cases: non-recourse stock loans as American call options\, ma
rgin call stock loans as American down-and-out barrier options with rebate
\, stocks loans under regime switching economy as American calls under reg
ime switching economy and capped stock loans as American capped calls.\n\n
https://conferences.maths.unsw.edu.au/event/4/contributions/522/
LOCATION:Kirby Institute\, UNSW Sydney Wallace Wurth-6-638 - Seminar Room
URL:https://conferences.maths.unsw.edu.au/event/4/contributions/522/
END:VEVENT
BEGIN:VEVENT
SUMMARY:PhD position advertisement
DTSTART;VALUE=DATE-TIME:20191124T233000Z
DTEND;VALUE=DATE-TIME:20191124T233500Z
DTSTAMP;VALUE=DATE-TIME:20230607T050004Z
UID:indico-contribution-4-524@conferences.maths.unsw.edu.au
DESCRIPTION:Speakers: Bishnu Lamichhane ()\, David Jenkins (University of
Newcastle NSW)\nhttps://conferences.maths.unsw.edu.au/event/4/contribution
s/524/
LOCATION:Kirby Institute\, UNSW Sydney Wallace Wurth-6-638 - Seminar Room
URL:https://conferences.maths.unsw.edu.au/event/4/contributions/524/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Opening welcome
DTSTART;VALUE=DATE-TIME:20191124T220000Z
DTEND;VALUE=DATE-TIME:20191124T220500Z
DTSTAMP;VALUE=DATE-TIME:20230607T050004Z
UID:indico-contribution-4-523@conferences.maths.unsw.edu.au
DESCRIPTION:https://conferences.maths.unsw.edu.au/event/4/contributions/52
3/
LOCATION:Kirby Institute\, UNSW Sydney Wallace Wurth-6-638 - Seminar Room
URL:https://conferences.maths.unsw.edu.au/event/4/contributions/523/
END:VEVENT
END:VCALENDAR